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The Mayo Clinic shares that those most at risk of low levels include (5): people who dont consume enough vitamin B12 in their diet people diagnosed with pernicious anemia people whove had gastric surgeries people with intestinal issues, such as celiac or Crohns disease People following a vegetarian diet are especially at risk of deficiency

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However, it is of note that the combined therapy is associated with infusion-related reactions and accounts for higher rates of thrombocytopenia and neutropenia than treatment with bortezomib or dexamethasone alone, which may cause harmful effects to patients (Figure 6b) [107]