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Prospective studies should incorporate clinically meaningful endpoints rather than surrogate mechanistic outcomes

The following medications are commonly used to help lower uric acid levels in the bloodstream: Allopurinol Allopurinol is a medication used to lower uric acid levels

10.1038/s41598-025-93124-z 114 XiangW.ZhengQ.LiuA.HuangS.ChenR.QiuJ.et al (2023)

Weissenborn K, Bokemeyer M, Krause J, Ennen J, Ahl B

Similarly to IGF-I, vascular endothelial growth factor (VEGF) affects the survival and proliferation of endothelial cells, neurons and astrocytes in the brain, suggesting a potential therapeutic application in PD [32]