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Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in ones diet that leads to a decrease in the consumption of such products such as a vegan , vegetarian, or low-fat diet can increase the chance of a person developing a B12 deficiency

The present study aimed to evaluate the effects of trimetazidine, alone or in combination with probiotics, on inflammation, oxidative stress, and ferroptosis-related pathways in 5-FUinduced intestinal mucositis in mice, with particular focus on the Nrf2/GPx4/SLC7A11 antioxidant axis

10.1001/archopht.118.5.615 164 Serrano-MoralesJ.-M.De-Hita-CantalejoC.Snchez-GonzlezM

In particular, the expression of the insulin receptor protein, which regulates energy metabolism, has been positively correlated with mammalian longevity (Ma S

A critical role of the IL-1-IL-1R signaling pathway in skin inflammation and psoriasis pathogenesis

Sohrabzadeh, E., Kalantari, K