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It was reported that metabolic activation of numerous other flavonoids was involved in or aggravated their toxicities (Table 1)

However, the GSH levels of the muscle tissue were reduced to only 50% after treatment of the worms for 24 h with 10 M BSO

Together, these findings depict a state of oxygen hypersensitivity in mitochondrial dysfunction, suggesting that oxygen metabolism is an important determinant of prognosis in mitochondrial disease and may play a role in its pathogenesis (Jain et al., 2016)

GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

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