bacterial and host-derived glutathione are required to activate prfa Modulation of virulence fitness by host Discovery of a glutathione utilization
Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species: Cell Host & Microbe Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA: Cell Chemical Biology Frontiers Redox regulation by reversible protein S thiolation in bacteria RCSB PDB 5LRS: The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione and a 30 bp operator PrfA box motif Full article: Signals behind Listeria monocytogenes virulence mechanisms Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as sources of essential cysteine Infection and Immunity
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