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, 26 , 509-522.e6 (2017)

(Supplementary Figure 4.1)

The antidepressant-like, pro-neurogenic and neuroprotective effects of exercise were associated with the FNDC5/Irisin pathway (Wang and Pan, 2016), promoting the expression of BDNF in various brain regions (Pignataro et al., 2022), reducing neuroinflammation, and decreasing the expression of epidermal growth factor receptors (EGFR) in mice (Table 2

Lou H, Kim S-K, Zaitsev E, Snell CR, Lu B, Loh YP (2005) Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e

FengYLiCJinHSunYJiangHLiYet al

The free-living algorithm evaluates the tremor, dyskinesia, and activity level separately and continuously throughout the day (i.e., whenever the participant wore the watch)