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In the presence of free iron ions, hydrogen peroxide (H 2 O 2 ) and superoxide (O 2 ) produce OH (hydroxyl radicals) via the Fenton and Haber-Weiss reactions ( in vivo is the most important chemical substance that initiates lipid peroxidation and causes DNA damage ( 2+ /Fe 3+ , iron ions near membrane lipids react with lipid peroxides to form new lipid peroxides and lipid oxygen free radicals, which further accelerate the chain reaction and eventually lead to cross-linking, polymerization, and inactivation of some lipids and functional macromolecular compounds ( Treatment of Iron Overload Iron chelating agents are the main treatment options for iron overload diseases

Unfortunately, because of the decreased sensitivity, many NK patients delay seeking treatment until the condition is quite advanced

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(PubMed) O'Callaghan B, Bosch AM, Houlden H