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doi: 10.1080/07315724.2019.1657515 12 SanzYCryanJFDeschasaux-TanguyMElinavELambrechtRVeigaP

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This complexity may, in part, explain why anti-inflammatory therapies targeting these mediators have yielded disappointing results in clinical trials

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So, why is this combination getting so much attention

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Des-IGF-1 affects glutamate receptor AMPAR binding protein (GRIP), N-ethylmaleimide-sensitive fusion protein (NSF), stargazin, and proteins that interact with C-kinase-1, which influence AMPA receptor anchoring, surface translocation, and synaptic targeting [72]

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While it does not enhance performance in healthy tissue , it ensures injured tissue regains pre-injury functionality, potentially reducing re-injury risk

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