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Although it is difficult to conclude that ROS are the primary cause of apoptosis in this context, it is more likely that both DPI and MitoQ cause irreversible damage to OXPHOS in MNA cells (23, 31)

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Injectable semaglutide 2.4 mg (Wegovy) produces somewhat greater weight loss than orforglipron: approximately 14.9% at 68 weeks in the STEP 1 trial versus 11.2% at 72 weeks with orforglipron 36 mg in ATTAIN-1