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Indeed, combination of natural selective HDAC inhibitors might increase the anticancer drug efficacy as demonstrated in the case of the natural HDAC6-selective inhibitor aceroside VIII (Ryu et al., 2015)

Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, and Stampfer MJ (1997)

Cancer 9 , e002189 (2021)

Journal of Immunology Research , 2021 , 1-9

IFN- 1b plus atorvastatin has been shown in some studies to significantly lower high-sensitivity C-reactive protein levels in patients, indicating an anti-inflammatory effect of atorvastatin in MS (281)

Given the beneficial effects of several precursors and inhibitors summarized above, these strategies may be promising for finding a therapeutic strategy for AD, either as lead molecules or in combination approaches with other classes of molecules or drugs, with several studies having been launched at the clinical level