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At therapeutic doses in healthy individuals, glutathione regenerates within hours to days after acetaminophen use

Bibcode:2021ChPap..75.6625A

The continued treatment with 1 M was done as this concentration is within range of the serum concentrations of the sum of tamoxifen and its metabolites in breast cancer patients treated with tamoxifen [24]

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Consistently, by ChIP assay, we detected significant NRF2 binding in Nqo1 and Slc7a11 loci, along with induced association of H3K4Me4 and H3K9Ac after DMF treatment (Fig