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Butterfield DA, Reed T, Perluigi M, De Marco C, Coccia R, Cini C, et al

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Baron, R., Dickenson, A

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KLOW has not been evaluated in formal human clinical trials, so any extrapolation to human safety is speculative

The activation of both types of IL-4 receptors leads to the phosphorylation of Janus kinase (JAK) 1, Jak2, and Tyk2, activating STAT-6 transcription factors and leading to the gene expression of target inflammatory mediators