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Non-erythropoietic: By design it does not stimulate erythropoiesis, avoiding the hematocrit/thrombotic risks associated with EPO

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Even some common medications, particularly those for managing acid reflux or diabetes, can interfere with this process over time

It is also worth noting that a large cluster of long heparan polymers on the cell surface could be associated with multiple dimeric c-MET/HGF complexes and in principle induce the higher-order oligomerization of c-METs, and potentially lead to the formation of even larger biomolecular condensates on the cell membrane

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Tivantinib (ARQ 197) is a staurosporine derivative and it represents the first non-ATP-competitive c-Met inhibitor that binds to the dephosphorylated c-Met kinase in vitro