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B12 (cobalamin) plays an essential role as a coenzyme in many biochemical processes that maintain the function of the nervous system

2.6 Culture and polarization of macrophages Peripheral blood mononuclear cells (PBMCs) were isolated from healthy controls by Ficoll-Paque PREMIUM density gradient (GE Healthcare, USA) centrifugation

PMID: 245 LiuYLiangSLeiYZhouYZhangYLiSet al

(2015) 10:e0137226

This increase was maintained following treatment with LPS

The suppression of NF-B activation by various probiotics consequently diminishes the production of these mediators, leading to an attenuated inflammatory response (254)