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Maehr H, Lee HJ, Perry B, Suh N, Uskokovic MR

Mounting data reveal intimate Nrf2NLRP3 crosstalk: Nrf2 activation limits the transcriptional priming of NLRP3, curtails mitochondrial ROS, and directly interferes with inflammasome assembly, whereas unchecked NLRP3 signaling feeds forward to inhibit Nrf2 and perpetuate oxidative damage (sciencedirect.com)

doi: 10.1016/j.tranon.2022.101340 63 ZhenNGuSMaJZhuJYinMXuMet al

Glutathione has been administered intravenously to treat chronic liver disease in humans

Glutathione is less available for other essential tasks, like skin repair and biological defence

Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione