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The simulations also found that Mechanism 1, in which the -DMAM group serves as a general base, is more likely due to a lower free energy barrier in the rate-limiting step

Journal of Antioxidant Research, 34(5), 1253-1265

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For example, RSL3, a GPX4 inhibitor, induces ferroptosis in pancreatic cancer but varies in effectiveness based on the KRAS mutations and metabolic adaptations

doi: 10.1007/s10653-019-00395-3 120 AhmadiKRoshan-MilaniSAsgharzadehFPourjabaliMFardAA