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Comprehensive research on the mechanistic aspects of drug abuse-mediated BBB dysfunction could identify better therapeutic targets

Cell Death Dis (2022) 134(13):115

Mammalian IgG expression can be performed to ensure that the produced antibodies comprise modified (e.g., glycosylated) properties of the mammalian proteins and/or to ensure that the antibody preparation is free of endotoxins and/or other contaminants that may be present in the protein preparation from the bacterial expression system

Sanchez AM, Papaleo E, Corti L, Santambrogio P, Levi S, Vigan P, et al

Hyperglycemic effects of hydrochlorothiazide and propranolol

It raises concerns that in certain patient populations, like non-diabetics or those with pre-existing mitochondrial dysfunction, metformin could inadvertently worsen the neuronal energy status, making its application for neuroprotection a delicate balance that requires a precise understanding of individuals brain bioenergetics