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Immunologist Mala Maini of University College London has used fine needle aspirates to assess a wide range of immune responses to HBV in the liver, and she's now collaborating with hepatologist Fabien Zoulim of the University of Lyon in France to see whether the technique can work for cccDNA studies

In the UbiCRest assay, polyubiquitin chains added to HMOX2 by MITOL were only digested in the presence of the universal deubiquitinating enzyme USP2 or the K63-linked polyubiquitin-specific deubiquitinating enzyme AMSH (Fig

Shahoumian VA Palo Alto Health Care System, Palo Alto, CA, USA Catherine Curtin Authors Devi Lakhlani Troy A