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The result is a greater reliance on fat for energy production, reduced muscle glycogen depletion, and (in some clinical studies) reduced lactic acid accumulation that can extend exercise capacity before fatigue

Relative AMPK111 activity on its substrate SAMStide in the presence of vehicle (Veh), BSA, 100 M linoleic acid (LA), 10 M linoleoyl-CoA (LA-CoA) or 100 M AMP (n = 5 biological independent samples) b

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Neurology 39 , 538541 (1989)

J Biol Chem 272:2346923472

Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates