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Preclinical studies have shown that GNK-301 can be used to detect the presence of the HERV-K ENV protein in a laboratory test and that it can then be used as a medicine to neutralize the harmful effects of HERV-K ENV, protecting neurons and preventing damage to the blood-brain barrier

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This is inconsistent with the substrate scope of characterised archaeal SAHHs/SIHHs as the subgroup of the tested euryarchaeal Mc SAHH, Me SAHH, Mh SAHH and Mt SAHH showed no activity for SIH cleavage