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Consistently, probiotic Lactobacillus plantarum A7 was reported to improve inflammatory and oxidative stress factors, which further indicated the beneficial effect of probiotic Lactobacillus plantarum A7 in DN patients (Miraghajani et al., 2017, 2019)

*Instrumental ADL refers to preparing meals, shopping for groceries or clothes, using the telephone, managing money, etc

Phase III clinical trials, most notably the 6-month randomized controlled study, revealed a significant dose-dependent adverse effect: while conservative dosing (20 mg/kg/day) stabilized cardiac indices, aggressive chelation (40 mg/kg/day) precipitated a significant worsening of ataxia and neurological symptoms [119]

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