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As early as 1982, Clark and Shay found that after mitochondria isolated and purified from antibiotic-resistant cells were transferred to antibiotic-sensitive cells, these antibiotic-sensitive cells acquired stable antibiotic resistance

The hematologic data of all subjects are summarized in Table 1

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Phenobarbital indirectly activates the constitutive active androstane receptor (car) by inhibition of epidermal growth factor receptor signaling