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Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

Critical examination of mller glia-derived in vivo neurogenesis in the mouse retina

338 Proper control groups are essential for evaluating drug efficacy

Garten et al., 2015)

[Abstract]2024 Jun;30(6):e14782

Interim results from the NCT04886001 trial demonstrated clinical efficacy of the combination: it significantly improved cognitive function in early AD patients (assessed by ADAS-Cog13, with enhanced effects in APOE4-negative subgroups) and reduced CSF p-tau pathology compared with placebo, alongside an acceptable safety profile