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Taking naproxen and tramadol together can increase the risk of serious side effects, particularly affecting your stomach and kidneys

It may also have a skin-lightening effect

This often results in: Abdominal cramping Bloating or gas Loose stools or diarrhea If you experience these symptoms shortly after increasing your dose, it is a strong signal from your body that you have exceeded your personal threshold

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Second, some tumors may increase proteins that bind to B12 in the blood