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Int J Mol Sci 14:96439684 Hasanuzzaman M, Nahar N, Hossain MS, Mahmud JA, Rahman A, Inafuku M, Oku H, Fujita M (2017) Coordinated actions of glyoxalase and antioxidant defense systems in conferring abiotic stress tolerance in plants

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Protandim activates Nrf2, which communicates with cells, instructing them to do what theyre already designed to do: up-regulate survival genes, genes that enable cells to survive in the face of stress from free radicals and other oxidants, and down-regulate other genes to help the body function at an optimal level

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TMAO activates its intracellular potential receptors, protein kinase R-like endoplasmic reticulum kinase (PERK), which further activates NLRP3 and NF-B that mediate pro-inflammatory responses