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AMPK serves as a metabolic sensor and regulates lipid and glucose metabolism, and metabolic alterations contribute to the progression of DMD [260] and were also recapitulated in mdx mice [261]

By targeting both GIP and GLP-1 receptors, tirzepatide mimics the actions of naturally occurring incretin hormones, leading to improved glucose metabolism and significant weight loss

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Glucagon receptor activation increases energy expenditure and promotes fat oxidation in ways that differ from earlier obesity medications

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