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All experiments were carried out in compliance with the National Institutes of Health (NIH) guidelines for the care and use of laboratory animals and were previously approved by the Ethics Committee on the Use of Animals of the Institute of Biomedical Sciences at the University of So Paulo

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iii) autophagy plays an important role in the control of the mucosal immune system

This activation increases the transcription of NLRP3 and pro-IL-1, establishing the necessary protein pool for subsequent inflammasome assembly (62)

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Long time alcohol consumption significantly triggers adipocyte apoptosis within adipose tissue in mice, enhances lipolysis, and promotes the liberation of NEFAs [213], along with the generation of proinflammatory cytokines [214]