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It should be noted that hepatocellular neoplasms might arise in severe hepatic fibrosis

Whilst the intrinsic factor-mediated absorption pathway can only process approximately 1.52 micrograms of B12 at a time, passive diffusion allows absorption of about 1% of higher doses

10.1073/pnas.2021073118 45 PeiZ.FlexederC.FuertesE.ThieringE.KoletzkoB.CramerC.et al (2013)

Similarly, ROS-induced ER stress triggers the unfolded protein response (UPR), which leads to further cell apoptosis and the immune system targeting melanocytes 56