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Acknowledgements This research was supported by the National Key R&D Program of China (2018YFC1313304, 2018YFC1313300), National Natural Science Foundation of China (81930065, 81871951), Natural Science Foundation of Guangdong Province (2019A1515010233, 2018B030306049), Pearl River S&T Nova Program of Guangzhou (201806010002), and CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-036)

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Non-synonymous SNPs, including rs373838463 at position L168, rs2107818892 at position F167, rs1261604097 at position F126, rs201944086 at position P77, and rs763687242 at position G75 were categorized as conserved, buried, and functionally important residues

Since vitamin B12 is also responsible for producing hormones and neurotransmitters, essential for keeping our brain and mental health balanced and fully functioning

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Since cyanocobalamin has to undergo this extensive conversion process, supplementation with methylcobalamin is preferable, and it is also the specific form of B12 in red blood cells, and throughout the nervous system