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Anthracyclines have a complex mechanism of action including inhibition of enzymes such as topoisomerase II, resulting in DNA double-strand breaks, intercalation into DNA and also generation of reactive oxygen species

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10.1016/j.bbrc.2018.11.055 48 IshimotoT.NaganoO.YaeT.TamadaM.MotoharaT.OshimaH.et al (2011)

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Amino acids metabolism Amino acid metabolism in cellular functions Amino acids, traditionally recognized as the fundamental components of protein biosynthesis, also play versatile roles as precursors for enzymes, signaling molecules, and essential metabolic intermediates that support cellular homeostasis and tissue remodeling [8, 47, 48]