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Nrf2 up-regulation contributed to RPE cell survival after exposure to CSE 12

These studies did not examine cobalt concentrations after long-term use, they wrote, therefore CPMA cannot and does not guarantee the products will not cause a sample to be over the threshold. The Canadian study isnt the only one to find how cobalt builds-up at maximum concentrations following repeated administration

Acknowledgements The authors disclose support for this work from national funds through the Portuguese Foundation for Science and Technology [CICS-UBI, UIDB/00709/2020 and ProMETAB, 029114 projects