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Lobetyolin, a polyacetylene glucoside derived primarily from the roots of Codonopsis pilosula, induces apoptosis by inhibiting ASCT2-mediated Gln uptake, thereby suppressing GC [59]

Levothyroxine (T4), commonly used to treat hypothyroidism, is well-absorbed in the gastrointestinal tract, with peak plasma levels typically occurring within 2 to 4 hours after ingestion (5)

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With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism