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NADPH oxidase- generated O 2 , besides NO scavenging, triggers eNOS uncoupling (the mechanisms are discussed in the next section), and uncoupled eNOS becomes itself a source of superoxide [19]

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Specifically, B12 is essential for: Fatty acid metabolism: It helps convert fatty acids into succinyl-CoA, which enters the Krebs cycle for ATP production

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The in vitro experiment also revealed acrolein adduction to Arg-307, forming six-membered heterocycle

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Biomaterials 308, 122544

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