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The macromolecules will be further catabolized in the tumor and stroma into metabolite fuels by processes such as autophagy, nucleic-acid degradation, and even glycogenolysis, by some of the mechanisms outlined below and addressed extensively elsewhere 3,27,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46

Similar content being viewed by others 1 Introduction Vitamin B12 is essential for DNA synthesis, methylation, and folate metabolism, especially to convert folate to its active form, synthesize purines, convert homocysteine into methionine, and produce S-adenosylmethionine, which is involved in over 100 methylation reactions

The Trx system also reduces peroxiredoxins which control reactive oxygen species (ROS) and hydrogen peroxide levels 19

doi: 10.3389/fendo.2022.816970 3 LiuHLiuHLiuCShangMWeiTYinP

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