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The dimers of NF-B are sequestered in the cytosol through noncovalent interactions with inhibitory proteins termed IBs [54, 55, 103, 104]

Previous studies showed that the mechanical properties of the implanted scaffold imposed a significant impact on chondrogenesis during cartilage matrix formation 31

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Fe 3+ can act as a catalase-like nanozyme to transform H 2 O 2 into O 2 , relieving the hypoxic condition in TME and boosting oxygen-based PDT and SDT

Our findings are consistent with these previous reports, as we observed attenuation of A plaques and tau pathology in CR-fed 3xTg mice