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Since cells contain DNA, and DNA contains purines, anything that increases the breakdown of cells in the body can lead to more uric acid and gout

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Nuclear STAT3 promotes autophagy through the transcriptional activation of autophagy-lysosomal genes, whereas cytoplasmic and mitochondrial STAT3 suppress autophagy by inhibiting the PKR and FOXO signaling pathways

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Impaired mitophagy has been associated with a variety of human diseases (e.g

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