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EpidemiologyGlobal and Local Insights The global prevalence of G6PD deficiency was estimated to be 4.9% (6), amounting to approximately 400 million people affected worldwide, making it the most prevalent human enzyme deficiency

GSH acts by scavenging reactive oxygen species (ROS) and chelating intracellular zinc (Zn), whose dysregulation exacerbates neuronal injury and contributes to ischemic cascades (10)

Glutathione is also proven to reverse melanins metabolism, lightening dark pigmentations

Epigallocatechin Gallate/L-Ascorbic AcidLoaded Poly--glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis

Applications of Glutathione in Cosmetic Formulations Glutathione is widely used in modern skincare formulations as a multifunctional brightening and anti-aging active, especially in products that target dullness, uneven tone, and early wrinkles

We estimated that with this sample size, the study would have 80% power to detect an absolute difference in the rate of improvement in ALT of 30 percentage points, with a two-sided type 1 error of 0.05