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In this review article, we describe the common metabolic profile that is shared between all of these high-risk groups and COVID-19

Apart from these factors, recent preclinical studies have shown that the pertinent metabolic processes are regulated by circadian rhythms, underscoring the significant impact of circadian disruptions on the development of MASLD and metabolic dysfunction-associated steatohepatitis (MASH) [125]

On the basis of the increased flux in TCA cycle, AMPK facilitates FOXO1-dependent IDH2 expression, and revitalizes the enzymatic activity of IDH2 by the PGC-1/SIRT3 pathway