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Isolauri, E., Majamaa, H., Arvola, T., et al

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The blood glucose levels in streptozotocin-treated mice were titrated to a non-toxic range with daily subcutaneously injections of long-acting insulin glargine (Fisher Scientific, NC0767732)

Although the patients were randomized to treatment groups, the patients/parents and healthcare providers (except the pediatric neurologist who evaluated EEG recordings) were not blinded to the treatment in a particular child, which could be a source of bias

GTP cyclohydrolase-1 (GCH1) can catalyse GTP to tetrahydrobiopterin to exert endogenous antioxidant effects and inhibit ferroptosis [79]