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In addition, keratinocytes from OLP patients showed higher levels of mRNA expression of inflammatory factors interleukin-6 (IL-6) and TNF- than normal oral epithelial keratinocytes

However, the chronic progression phase of periodontitis involves numerous non-infectious metabolic drivers, including iron overload resulting from recurrent bleeding and diminished antioxidant defenses caused by aging or diabetes (70)

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High intracellular glucose concentration develops when hyperthyroidism induces IR in GD patients, because brain cells like cerebral microvascular endothelial cells, pericytes, and astrocytes are unable to slow down their glucose transport rate (122, 123)

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