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(59) Guyton, K

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In an MPTP-induced Parkinson's disease animal model, intracerebroventricular injection of PBzyme decreases dopaminergic degradation and inhibits neuroinflammation by downregulating the activation of microglial nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasomes and caspase-1 by scavenging reactive oxygen species which ultimately leads to microglia pyroptosis (Ma et al., 2022)

Clinical and physiologic data

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For electron microscopy examination, liver tissues were prefixed after harvesting immediately with 1.5% glutaraldehyde and 0.8% paraformaldehyde (0.1 mol/L cacodylate buffer) at room temperature and postfixed in an aqueous solution of 1% OsO 4 and 1.5% K 4 (FeCN) 6