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Due to their ability to adapt to the harsh, nutrient-poor IVD microenvironr potential to effectively differentiate into NP-like cells, NPPCs have emerged as a promising candidate for cell-based regenerative therapies aimed at IVD repair

Blog post originally written by the AllStripes community team

X.FengY.LiuD.WangZ

Lancet Respir Med 5(3):162164 Chun SH, Lee HA, Lee KB, Kim SH, Park KY, Lee KW (2016) Effects of glycated Whey protein concentrate on Pro-inflammatory cytokine expression and phagocytic activity in RAW264.7 macrophages

Upon activation, HSF1 trimers translocate to the nucleus and bind to heat shock elements (HSEs) in the promoters of target genes, thereby increasing the transcription of HSP70s, which then undergo degradation or re-monomerization (Vihervaara and Sistonen, 2014)