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The main controversy with Kashin-Beck disease being linked to Selenium deficiency is that the pathogenesis is likely multifactorial in nature

AhCre and p21 / ( Cdkn1a tm1Led ) mice were sourced from Owen Sansom (Cancer Research UK, Beatson Institute, Glasgow) 28,29 , Fh fl/fl mice kindly provided by Iain Tomlinson (University of Oxford) 19 and all were maintained on a C57Bl6 background

doi: 10.1038/s41392-021-00658-5 5 Sordo-BahamondeCLorenzo-HerreroSGonzalez-RodriguezAPMartnez-PrezARodrigoJPGarca-PedreroJMet al

Reduced glutathione (GSH) has shown slightly better results than oxidized forms (GSSG) in some studies

* L-Lysine: An essential amino acid for collagen production, immune function, and calcium absorption