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GSH production is regulated by inflammation-associated pathways, and the disruption of STAT3 signaling reduces GSH levels, leading to an increased accumulation of ROS

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LUAD is a principal malignancy associated with several multi-organ cancer predisposition syndromes resulting from germline mutation of tumour-suppressor genes (for example, TP53, PTEN or LKB1 ) 217

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Poor memory and cognition Although it is well known that benzodiazepines impair memory and some cognitive functions, particularly the ability to sustain attention, some long-term users complain of continued loss of intellectual abilities persisting after withdrawal