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Selective renal Grk4 knockdown, via chronic renal cortical interstitial-selective infusion of Grk4 antisense oligodeoxynucleotides, increases urine flow and ameliorates the sodium retention and elevated blood pressure of SHRs [79, 80]

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The cellular localization of GCL and GS supports the need to metabolically integrate maintenance of glutathione pools in both the cytosol and plastid

doi:10.1016/j.intimp.2019.106067 37

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