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F., Finotto, S

By investigating the dysregulation of glutamine metabolism, researchers can unravel the metabolic imbalances associated with these conditions

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Using in vitro human models, we showed that these thiomethyl metabolites are directly linked to NAPQI detoxification since they are mainly formed after exposure to glutathione-derived conjugates via an overlooked pathway called the thiomethyl shunt

After 48 h, cells were stimulated with 50 ng/mM PMA and 1 g/mL ionomycin, followed by 3 h incubation with GolgiStop to evaluate intracellular cytokine secretion