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Pickova D, Ostry V, Toman J, Malir F

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Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1)

Lower TIMP-2 has been reported in other psychiatric disorders, including MDD (63), and schizophrenia (64)

Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, making this finding especially relevant for clinical application