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Pasello et al reported that this agent effectively reversed cisplatin resistance in osteosarcoma, alluding toward potentially improved clinical outcomes when using a combination of NBDHEX and cisplatin

Many diseases, such as cancers, cardiovascular diseases, neurodegenerative diseases, metabolic disorders, liver diseases, autoimmune diseases, and ocular diseases, are closely associated with mitochondrial dysfunction (Fig

They have reported that oxidative stress and inflammatory pathways can trigger RyR(Ryanodine receptor) leakage