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JAMA Neurol 75(4):444452

& Fiskum, G

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(PubMed) DSIP also modulates neurotransmitter systems

Ferroptosis not only functions as an effector of neuronal and tumor cell death but also regulates immune cell activation, differentiation, and polarization, while immune-derived signals reciprocally shape ferroptosis susceptibility ( In this review, we provide a comprehensive synthesis of current knowledge on ferroptosis in the CNS, with a particular emphasis on its interactions with immune cells across neurodegenerative diseases, demyelinating disorders, and glioma