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APR-017 treatment led to increased ROS level and decreased GSH level in PDCs with low expression of VRK2 rather than PDCs with high expression of VRK2 (Fig

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Lipids are most abundant in the human brain among all tissues except adipose tissue ( Enzymes like acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are central to incorporating PUFAs into membranes, sensitizing cells to ferroptosis ( As non-heme iron-containing dioxygenases, lipoxygenases (LOXs) directly catalyze the peroxidation of PUFAs, both free and esterified in phospholipids (77, 78)

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